Influence of polymorphisms in TNF-α and IL1β on susceptibility to alcohol induced liver diseases and therapeutic potential of miR-124-3p impeding TNF-α/IL1β mediated multi-cellular signaling in liver microenvironment

Background and aimsAlcoholic liver disease (ALD) is the leading cause of the liver cirrhosis related death worldwide. Excessive alcohol consumption resulting enhanced gut permeability which trigger sensitization of inflammatory cells to bacterial endotoxins and induces secretion of cytokines, chemok...

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Główni autorzy:	Debanjali Dasgupta, Suchandrima Ghosh, Indrashish Dey, Swagata Majumdar, Saheli Chowdhury, Subhas Das, Sanjana Banerjee, Mehelana Saha, Amit Ghosh, Neelanjana Roy, Alak Manna, Sukanta Ray, Shaleen Agarwal, Pradeep Bhaumik, Simanti Datta, Abhijit Chowdhury, Soma Banerjee
Format:	Artigo
Język:	Inglês
Wydane:	Frontiers Media S.A. 2023-12-01
Seria:	Frontiers in Immunology
Hasła przedmiotowe:	alcohol induced liver diseases microRNA-124-3p TNF-α IL1β alcohol ALD
Dostęp online:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1241755/full
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