Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency

The pathways involved in exit from pluripotency in human embryonic stem cells are poorly understood. Here, the authors performed a CRISPR-based screen to identify genes that promote exit from naïve pluripotency and find a role for folliculin (FLCN) by regulating the mTOR and Wnt pathways.

Bibliografiske detaljer

Principais autores:	J. Mathieu, D. Detraux, D. Kuppers, Y. Wang, C. Cavanaugh, S. Sidhu, S. Levy, A. M. Robitaille, A. Ferreccio, T. Bottorff, A. McAlister, L. Somasundaram, F. Artoni, S. Battle, R. D. Hawkins, R. T. Moon, C. B. Ware, P. J. Paddison, H. Ruohola-Baker
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2019-02-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-018-08020-0
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