Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isolates Leads to Frequent Development of Broad and Elite Antibody Neutralization in HIV-1-Infected Individuals

ABSTRACT A minority of HIV-1-infected patients produce broadly neutralizing antibodies (bNAbs). Identification of viral and host correlates of bNAb production may help develop vaccines. We aimed to characterize the neutralizing response and viral and host-associated factors in Angola, which has one...

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Autores principales:	Francisco Martin, José Maria Marcelino, Claudia Palladino, Inês Bártolo, Susana Tracana, Inês Moranguinho, Paloma Gonçalves, Rita Mateus, Rita Calado, Pedro Borrego, Thomas Leitner, Sofia Clemente, Nuno Taveira
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology 2022-12-01
Colección:	Microbiology Spectrum
Materias:	Angola Env diversity HIV-1 infection broadly neutralizing antibodies bNAbs Env-specific antibodies
Acceso en línea:	https://journals.asm.org/doi/10.1128/spectrum.01634-22
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