Using in vitro data to derive acceptable exposure levels for environmental chemicals: A case study on p,p’-DDE obesogenicity

Background: Current acceptable exposure levels are largely based on animal models, which are costly, time-consuming, and may poorly predict adverse outcomes in humans. Alternative testing methods are needed to adequately tackle the large number of environmental chemicals. Objective: To evaluate a me...

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Detalhes bibliográficos

Principais autores:	Sherri Bloch, Laura Lévêque, Marie-Hélène Nicolas, James M. Armitage, Iva Šeflová, Jan Jedlička, Dana Müllerová, Jitka Kuncová, Ella Atlas, Maryse F. Bouchard, P. Charukeshi Chandrasekera, Marc-André Verner
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-11-01
coleção:	Environment International
Assuntos:	P,p’-dichlorodiphenyldichloroethylene (p,p’-DDE) In vitro to in vivo extrapolation (IVIVE) New Approach Methodologies (NAMs) Benchmark dose modeling Mass-balance modeling Toxicokinetic modeling
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0160412025006506
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