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Advances in modeling the Charcot-Marie-Tooth disease: Human induced pluripotent stem cell-derived Schwann cells harboring SH3TC2 variants

Human induced pluripotent stem cells (hiPSCs) represent a powerful tool for investigating neuropathological disorders, such as Charcot-Marie-Tooth disease (CMT), the most prevalent inherited peripheral neuropathy, where the cells of interest are hardly accessible. Advancing the development of approp...

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Principais autores: Camille Loret, Camille Scherrer, Amandine Rovini, Ioanna Pyromali, Pierre-Antoine Faye, Angélique Nizou, Franck Sturtz, Frédéric Favreau, Anne-Sophie Lia
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-06-01
coleção:European Journal of Cell Biology
Assuntos:
HiPSCs1
CRISPR-Cas92
Disease cellular model3
Charcot-Marie-Tooth (CMT)4
SH3TC25
Schwann cells6
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S017193352500010X
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