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Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Abstract Temporal lobe epilepsy (TLE), the most common form of epilepsy, is primarily characterized by hippocampal sclerosis (HS). Microglia reactivity is a critical component of TLE pathogenesis, and apolipoprotein E (APOE) may be a potential mediator of these processes. However, its role in TLE pr...

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Principais autores: Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-01-01
Serier:Advanced Science
Fag:
apolipoprotein E
metabolomics
microglia
neuroinflammation
neuronal excitability
temporal lobe epilepsy
Online adgang:https://doi.org/10.1002/advs.202505778
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