Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone

Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (GRK3) is an important negative regulator of G...

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Bibliografische Detailangaben

Hauptverfasser:	Emily M. Rabjohns, Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman, Jessica L. Bowser, Kathryn Berg, Sachin Wani, Stuart H. Ralston, Matthew J. Hilton, Teresa K. Tarrant
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-03-01
Schriftenreihe:	Cells
Schlagworte:	bone osteoclast Paget’s Paget’s disease of bone G protein-coupled receptor kinase G protein-coupled receptor
Online-Zugang:	https://www.mdpi.com/2073-4409/12/7/981
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