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Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure

Phosphodiesterase 4 (PDE4) is a key regulator of cyclic adenosine monophosphate (cAMP) signalling in cardiomyocytes, controlling contractility, calcium handling, and hypertrophic responses. PDE4 provides spatial and temporal precision to cAMP signalling, particularly under β-adrenergic stimulation,...

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Principais autores: Ivan Sherstnev, Aleksandra Judina, Giovanni Battista Luciani, Alessandra Ghigo, Emilio Hirsch, Julia Gorelik
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2025-03-01
Series:Cells
Assuntos:
Phosphodiesterase 4
cAMP signalling
cardiomyocyte
β-adrenergic signalling
arrhythmia
cAMP compartmentation
Acceso en liña:https://www.mdpi.com/2073-4409/14/6/460
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