pKr-2 induces neurodegeneration via upregulation of microglial TLR4 in the hippocampus of AD brain

We recently demonstrated that prothrombin kringle-2 (pKr-2) derived from blood-brain barrier (BBB) disruption could induce hippocampal neurodegeneration and object recognition impairment through neurotoxic inflammatory responses in the five familial Alzheimer's disease mutation (5XFAD) mice. In the...

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Detalhes bibliográficos

Principais autores:	Sehwan Kim, Chanchal Sharma, Minsang Shin, Hyung-Jun Kim, Jaekwang Kim, Sang Ryong Kim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-03-01
coleção:	Brain, Behavior, & Immunity - Health
Assuntos:	Prothrombin kringle-2 Alzheimer's disease Toll-like receptor 4 Microglia Hippocampus Neuroinflammation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2666354623000078
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