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Differential transcriptomic modulation by histone deacetylase inhibitor SAHA in LUAD and LUSC

Abstract Background Histone deacetylases (HDACs) are central epigenetic regulators in non-small cell lung cancer (NSCLC), yet responses to HDAC inhibitors (HDACi) vary markedly between lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC). We asked how the pan-HDAC inhibitor suberoylanilide...

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Autors principals: Fei Wang, Qingjun Yang, Lei Shu, Huiyu Cen, Yating Huang, Xiaojun Ma, Yinshan Lin, Xiaoling Guan, Chen Wang, Xihua Fu, Guoxing You, Xi-Yong Yu, Lingmin Zhang, Jianfen Su
Format: Artigo
Idioma:Inglês
Publicat: BMC 2026-01-01
Col·lecció:Clinical Epigenetics
Matèries:
NSCLC
HDAC inhibitors
SAHA
Transcriptomic modulation
Personalized therapy
Accés en línia:https://doi.org/10.1186/s13148-026-02051-x
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