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Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

Retinoic acid-inducible gene I (RIG-I) activates mitochondrial antiviral signaling proteins, initiating the antiviral response. RIG-I and RNF135, a ubiquitin ligase regulator, are missing in domestic chickens but conserved in mallard ducks. The chickens’ RIG-I loss was long believed to be linked to...

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Principais autores: Hicham Sid, Theresa von Heyl, Sabrina Schleibinger, Romina Klinger, Leah Heymelot Nabel, Hanna Vikkula, Rodrigo Guabiraba, Vanaique Guillory, Ryan Scicluna, Mohanned Naif Alhussien, Brigitte Böhm, Benjamin Schade, Daniel Elleder, Samantha Sives, Lonneke Vervelde, Sascha Trapp, Benjamin Schusser
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-10-01
Serier:Frontiers in Immunology
Fag:
avian influenza virus
RIG-I
RNF135
transgenic chicken
duck
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1680791/full
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