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Hyaluronan-mediated motility receptor regulating the Wnt/β-catenin signaling resulting in hepatocellular carcinoma by inhibiting the phosphorylation activity of GSK-3β

Abstract Background Hepatocellular carcinoma (HCC), the most common primary liver cancer, remains a major global health burden due to its aggressive metastatic behavior and poor prognosis. Clarification of the molecular basis underlying metastasis and recurrence is essential for advancing therapeuti...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Yumei Zhang, Zhiming Zhang, Zongcai Yan, Meiling He, Xiuwen Wang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-10-01
Schriftenreihe:European Journal of Medical Research
Schlagworte:
HMMR
Wnt/β-catenin signaling
Hepatocellular carcinoma
Phosphorylation activity
GSK-3β
Online-Zugang:https://doi.org/10.1186/s40001-025-03372-y
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