A cfDNA methylation-based tissue-of-origin classifier for cancers of unknown primary

Abstract Cancers of Unknown Primary (CUP) remains a diagnostic and therapeutic challenge due to biological heterogeneity and poor responses to standard chemotherapy. Predicting tissue-of-origin (TOO) molecularly could help refine this diagnosis, with tissue acquisition barriers mitigated via liquid...

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Главные авторы:	Alicia-Marie Conway, Simon P. Pearce, Alexandra Clipson, Steven M. Hill, Francesca Chemi, Dan Slane-Tan, Saba Ferdous, A. S. Md Mukarram Hossain, Katarzyna Kamieniecka, Daniel J. White, Claire Mitchell, Alastair Kerr, Matthew G. Krebs, Gerard Brady, Caroline Dive, Natalie Cook, Dominic G. Rothwell
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2024-04-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-024-47195-7
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