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An integrative multiparametric approach stratifies putative distinct phenotypes of blast phase chronic myelomonocytic leukemia

Summary: Approximately 30% of patients with chronic myelomonocytic leukemia (CMML) undergo transformation to a chemo-refractory blastic phase (BP-CMML). Seeking novel therapeutic approaches, we profiled blast transcriptomes from 42 BP-CMMLs, observing extensive transcriptional heterogeneity and poor...

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Kaydedildi:
Asıl Yazarlar: Kristian Gurashi, Yu-Hung Wang, Fabio M.R. Amaral, Katherine Spence, Rachel Cant, Chi-Yuan Yao, Chien-Chin Lin, Christopher Wirth, David C. Wedge, Guillermo Montalban-Bravo, Simona Colla, Hwei-Fang Tien, Tim C.P. Somervaille, Kiran Batta, Daniel H. Wiseman
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2025-02-01
Seri Bilgileri:Cell Reports Medicine
Konular:
CMML
blast phase
secondary AML
MDS/MPN
leukemic transformation
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2666379125000060
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