The size of CD8+ infiltrating T cells is a prognostic marker for esophageal squamous cell carcinoma

Abstract In many malignancies, an increased number of tumor-infiltrating lymphocytes (TILs) is recognized as a favorable prognostic factor, with exceptions such as renal cell carcinoma. However, the clinical significance of TIL size remains unclear. T-cell activation by mitogens increases cell size,...

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Detalhes bibliográficos

Principais autores:	Kengo Shigehara, Noriko Kawai, Tomohide Shirosaki, Yuma Ebihara, Aiko Murai, Akari Takaya, Serina Tokita, Kenta Sasaki, Naoki Shijubou, Terufumi Kubo, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yutaka Hatanaka, Tomoko Mitsuhashi, Toshiaki Shichinohe, Yoshihiko Hirohashi, Satoshi Hirano, Toshihiko Torigoe
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-07-01
coleção:	Scientific Reports
Assuntos:	Esophageal squamous cell carcinoma Tumor-infiltrating lymphocytes CD8 Lymphocyte size
Acesso em linha:	https://doi.org/10.1038/s41598-025-10885-3
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