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Azetidine synthesis by La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines

Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-se...

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Principais autores: Yuse Kuriyama, Yusuke Sasano, Yoshiharu Iwabuchi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-09-01
coleção:Frontiers in Chemistry
Assuntos:
azetidine
epoxide
catalytic reaction
regioselectivity
cyclization
Lewis acid
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fchem.2023.1251299/full
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