MAVS signaling of long-lived brain-resident myeloid cells is needed during viral encephalitis to adjust the transcriptome of CNS infiltrating CD8+ T cells

Abstract Neurotropic viruses like vesicular stomatitis virus (VSV) can infect the central nervous system (CNS) through the olfactory route. Following intranasal instillation, VSV moves along the axons of olfactory sensory neurons to the olfactory bulb. While within the olfactory bulb the spread of t...

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Hlavní autoři:	Andreas Pavlou, Luca Ghita, Felix Mulenge, Inken Waltl, Olivia Luise Gern, Pia-Katharina Larsen, Bibiana Costa, Veronica Duran, Lena Mareike Busker, Shelly J. Robertson, Yvonne Lueder, Stephan Halle, Reinhold Förster, Sonja M. Best, Martin Stangel, Ulrich Kalinke
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-07-01
Edice:	Journal of Neuroinflammation
Témata:	Microglia CD8+ T cells Brain infection Cross-presentation CNS MAVS signaling
On-line přístup:	https://doi.org/10.1186/s12974-025-03497-1
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