Activation of PI3K/AKT/mTOR signaling axis by UBE2S inhibits autophagy leading to cisplatin resistance in ovarian cancer

Abstract Background Epithelial ovarian cancer (OC) is the fourth leading cause of cancer-related deaths in women, with a 5-year survival rate of 30%-50%. Platinum resistance is the chief culprit for the high recurrence and mortality rates. Several studies confirm that the metabolic regulation of ubi...

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Detalhes bibliográficos

Principais autores:	Mengjun Zhang, Jialin Wang, Yan Guo, Haodi Yue, Lindong Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-12-01
coleção:	Journal of Ovarian Research
Assuntos:	Epithelial OC Platinum resistance Ubiquitin-conjugating enzyme E2S Autophagy
Acesso em linha:	https://doi.org/10.1186/s13048-023-01314-y
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