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Numb-PRRL promotes TGF-β1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer

Abstract Isoform-specific functions of Numb in the development of cancers, especially in the initiation of epithelial-to-mesenchymal transition (EMT) remains controversial. We study the specific function of Numb-PRRL isoform in activated EMT of pancreatic ductal adenocarcinoma (PC), which is disting...

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Auteurs principaux: Weiwei Sheng, Jingtong Tang, Rongxian Cao, Xiaoyang Shi, Yuteng Ma, Ming Dong
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2022-02-01
Collection:Cell Death and Disease
Accès en ligne:https://doi.org/10.1038/s41419-022-04609-y
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