Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis

Abstract Hypermutated neoantigens in cancers with DNA mismatch repair deficiency (dMMR) are prerequisites for favorable clinical responses to immune-checkpoint blockade (ICB) therapy. However, TMB is not significantly associated with favorable prognosis from Preclinical and clinical studies. It impl...

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Bibliografiske detaljer

Principais autores:	Huiyan Li, Hengli Ni, Ying Li, Aijun Zhou, Xiaokang Qin, Yuqing Li, Liheng Che, Hui Mo, Chao Qin, Jianming Li
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2024-05-01
Serier:	Cell Death Discovery
Online adgang:	https://doi.org/10.1038/s41420-024-01984-7
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