Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21low B cells in hepatitis C virus-cured mixed cryoglobulinemia

IntroductionHepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of B cells expressing B cell receptors (BCRs), often encoded by the VH1-69 variable gene, endowed with both rheumatoid factor (RF) and anti-HCV specificity. These cells display an atypical CD21low phen...

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Principais autores:	Martina Del Padre, Ramona Marrapodi, Ylenia A. Minafò, Eva Piano Mortari, Giovanna Radicchio, Chiara Bocci, Laura Gragnani, Alessandro Camponeschi, Stefania Colantuono, Lucia Stefanini, Stefania Basili, Rita Carsetti, Massimo Fiorilli, Milvia Casato, Marcella Visentini
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-02-01
coleção:	Frontiers in Immunology
Assuntos:	mixed cryoglobulinemia rheumatoid factor autoantigen CD21low B cells exhaustion BCR/TLR9 crosstalk
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1094871/full
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