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Epicatechin gallate and its analogues interact with sortase A and β-lactamase to suppress Staphylococcus aureus virulence

Staphylococcus aureus sortase A can anchor virulence proteins, which are responsible for bacterial adhesion, biofilm formation, and inflammation, to the cell membrane surface. The ability of β-lactam antibiotics to combat S. aureus infections is limited by the presence of β-lactamases in this pathog...

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Bibliografische Detailangaben
Hauptverfasser: Fei Teng, Lihui Wang, Jingyao Wen, Zizeng Tian, Guizhen Wang, Liping Peng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2025-03-01
Schriftenreihe:Frontiers in Cellular and Infection Microbiology
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1537564/full
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