Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations

Abstract Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disease. Here we studied the differences and commonalities between the transcriptome...

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Autores principales:	Janne Koskimäki, Dongdong Zhang, Yan Li, Laleh Saadat, Thomas Moore, Rhonda Lightle, Sean P. Polster, Julián Carrión-Penagos, Seán B. Lyne, Hussein A. Zeineddine, Changbin Shi, Robert Shenkar, Sharbel Romanos, Kenneth Avner, Abhinav Srinath, Le Shen, Matthew R. Detter, Daniel Snellings, Ying Cao, Miguel A. Lopez-Ramirez, Gregory Fonseca, Alan T. Tang, Pieter Faber, Jorge Andrade, Mark Ginsberg, Mark L. Kahn, Douglas A. Marchuk, Romuald Girard, Issam A. Awad
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2019-08-01
Colección:	Acta Neuropathologica Communications
Materias:	Cerebral cavernous malformation Cavernous angioma Hemangioma Ccm3 Mouse model Transcriptome
Acceso en línea:	http://link.springer.com/article/10.1186/s40478-019-0789-0
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