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Opposing fates: a bipolar cellular model for FMDV replication shaped by 12C6+heavy-ion mutagenesis

IntroductionBy pioneering the use of an 80 MeV/u 12C6+ heavy-ion beam for mutagenesis, we have engineered a stably polarized BHK-21 cell model for FMDV replication.MethodsThis approach yielded two distinct clones: a highly antiviral line (BHK-5) and a highly proviral line (BHK-7). Multi-omics analys...

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Principais autores: Xiangdong Song, Yan Cui, Fanglan An, Yajun Li, Jianping Liang, Shiyu Tao, Xuerong Liu
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2026-01-01
סדרה:Frontiers in Cellular and Infection Microbiology
נושאים:
12C6+ heavy-ion
BHK-21
transcription factor
FMDV
BHK-21 cell line
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1715061/full
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