Immunological characterization of IgG subclass deficiency reveals decreased Tregs and increased circulating costimulatory and regulatory immune checkpoints

BackgroundImmunoglobulin G subclass deficiencies (IgGsd) comprise a wide clinical spectrum from no symptoms to repeated respiratory infections and risk for the development of lung damage. Our aims were to investigate whether the immunological phenotype of IgGsd patients on and off immunoglobulin rep...

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Principais autores:	Per Wågström, Maria Hjorth, Daniel Appelgren, Janne Björkander, Charlotte Dahle, Mats Nilsson, Åsa Nilsdotter-Augustinsson, Jan Ernerudh, Sofia Nyström
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-08-01
coleção:	Frontiers in Immunology
Assuntos:	predominantly antibody deficiency IgG subclass deficiency Ig replacement therapy T cells B cells Tregs
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1442749/full
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