Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease

Regulatory T-cells (Treg) are critical for the maintenance of immune homeostasis and tolerance induction. While the immunosuppressive mechanisms of Treg have been extensively investigated for decades, the mechanisms responsible for Treg cytotoxicity and their therapeutic potential in regulating immu...

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Principais autores:	Sara Bolivar-Wagers, Jemma H. Larson, Sujeong Jin, Bruce R. Blazar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-04-01
coleção:	Frontiers in Immunology
Assuntos:	regulatory T-cell tTreg pTreg iTreg cytotoxic GVHD
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.864748/full
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