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Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex

Summary: The human cerebral cortex is specialized into regions, but little is known about how human cellular lineages shape cortical regional variation and neuronal cell-type distribution during development. Here, we map single-cell lineages of human cortical regions and neuronal subtypes using >1,0...

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Principais autores: Vinayak V. Viswanadham, Sonia N. Kim, Emre Caglayan, Ryan N. Doan, Yanmei Dou, Sara Bizzotto, Sattar Khoshkhoo, August Yue Huang, Rebecca Yeh, Brian H. Chhouk, Alex Truong, Kathleen M. Chappell, Marc Beaudin, Alison Barton, Shyam K. Akula, Yifan Zhao, Lariza Rento, Michael Lodato, Ryan A. Szeto, Javier Ganz, Pengpeng Li, Jessica W. Tsai, Robert Sean Hill, Peter J. Park, Christopher A. Walsh
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-11-01
coleção:Cell Reports
Assuntos:
CP: neuroscience
CP: genomics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S221112472501229X
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