The glycine N-acyltransferases, GLYAT and GLYATL1, contribute to the detoxification of isovaleryl-CoA - an in-silico and in vitro validation
Isovaleric acidemia (IVA), due to isovaleryl-CoA dehydrogenase (IVD) deficiency, results in the accumulation of isovaleryl-CoA, isovaleric acid and secondary metabolites. The increase in these metabolites decreases mitochondrial energy production and increases oxidative stress. This contributes to t...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Association for the Advancement of Science (AAAS)
2023-01-01
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| Serie: | Computational and Structural Biotechnology Journal |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S2001037023000430 |
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