Real-time <it>in vivo </it>imaging of <it>p16</it><sup><it>Ink4a </it></sup>gene expression: a new approach to study senescence stress signaling in living animals
<p>Abstract</p> <p>Oncogenic proliferative signals are coupled to a variety of growth inhibitory processes. In cultured primary human fibroblasts, for example, ectopic expression of oncogenic Ras or its downstream mediator initiates cellular senescence, the state of irreversible cell cycle arrest, t...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2010-01-01
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| Serier: | Cell Division |
| Online adgang: | http://www.celldiv.com/content/5/1/1 |
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