Sarcosine sensitizes lung adenocarcinoma to chemotherapy by dual activation of ferroptosis via PDK4/PDHA1 signaling and NMDAR-mediated iron export

Abstract Background Ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, is associated with chemoresistance in lung adenocarcinoma (LUAD). This study aims to investigate the role of sarcosine in ferroptosis and its underlying mechanisms. Methods An RSL3-induced ferroptosi...

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Hauptverfasser:	Guangyao Shan, Yunyi Bian, Shencheng Ren, Zhengyang Hu, Binyang Pan, Dejun Zeng, Zhaolin Zheng, Hong Fan, Guoshu Bi, Guangyu Yao, Cheng Zhan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-04-01
Schriftenreihe:	Experimental Hematology & Oncology
Schlagworte:	Sarcosine Ferroptosis Lung adenocarcinoma Chemotherapy Organoids
Online-Zugang:	https://doi.org/10.1186/s40164-025-00657-0
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