Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14

Spinocerebellar ataxias (SCAs) are hereditary diseases leading to Purkinje cell degeneration and cerebellar dysfunction. Most forms of SCA are caused by expansion of CAG repeats similar to other polyglutamine disorders such as Huntington's disease. In contrast, in the autosomal dominant SCA-14 the d...

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Detalhes bibliográficos

Principais autores:	Jingmin Ji, Melanie L. Hassler, Etsuko Shimobayashi, Nagendher Paka, Raphael Streit, Josef P. Kapfhammer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2014-10-01
coleção:	Neurobiology of Disease
Assuntos:	Spinocerebellar ataxia type 14 Protein kinase C gamma Purkinje cell dendritic development Transgenic mouse model
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996114001661
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