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SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

Abstract Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling remains unknown. Based on a screening pan...

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Kaydedildi:
Asıl Yazarlar: Shuxin Liang, Changlei Bao, Zi Yang, Shiyun Liu, Yanan Sun, Weitao Cao, Ting Wang, Tae-Hwi Schwantes-An, John S. Choy, Samisubbu Naidu, Ang Luo, Wenguang Yin, Stephen M. Black, Jian Wang, Pixin Ran, Ankit A. Desai, Haiyang Tang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2023-03-01
Seri Bilgileri:Signal Transduction and Targeted Therapy
Online Erişim:https://doi.org/10.1038/s41392-023-01368-w
Etiketler: Etiketle
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