Clinically meaningful changes in cognitive and functional outcomes in a population‐based study of cognitive aging

Abstract INTRODUCTION Research is limited regarding meaningful change thresholds for individual patients on clinical outcome assessments (COAs) frequently used in clinical trials for Alzheimer's disease and related dementias (ADRD), particularly in population‐based studies early in the disease cours...

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Principais autores:	Jeremiah A. Aakre, Anna M. Castillo, Jonathan Graff‐Radford, Prashanthi Vemuri, Mary M. Machulda, Clifford R. Jack Jr, David S. Knopman, Ronald C. Petersen, Maria Vassilaki
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2025-07-01
Series:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Assuntos:	clinical outcome assessments clinically meaningful decline mild cognitive impairment within‐patient change
Acceso en liña:	https://doi.org/10.1002/trc2.70160
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