METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

Abstract Background METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF...

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Главные авторы:	Jie Han, Jing-zi Wang, Xiao Yang, Hao Yu, Rui Zhou, Hong-Cheng Lu, Wen-Bo Yuan, Jian-chen Lu, Zi-jian Zhou, Qiang Lu, Ji-Fu Wei, Haiwei Yang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2019-06-01
Серии:	Molecular Cancer
Предметы:	METTL3 Bladder cancer m6A miR221/222 PTEN
Online-ссылка:	http://link.springer.com/article/10.1186/s12943-019-1036-9
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