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α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?

Synucleinopathies are a heterogeneous group of neurodegenerative diseases with amyloid deposits that contain the α-synuclein (SNCA/α-Syn) protein as a common hallmark. It is astonishing that aggregates of a single protein are able to give rise to a whole range of different disease manifestations. Th...

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Principais autores: Simon Oliver Hoppe, Gamze Uzunoğlu, Carmen Nussbaum-Krammer
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-06-01
coleção:Biomolecules
Assuntos:
alpha-synuclein
synucleinopathies
prions
prion-like propagation
amyloid
conformational strains
Acesso em linha:https://www.mdpi.com/2218-273X/11/7/931
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