Platelet-rich plasma alleviates endoplasmic reticulum stress via the IGF1R-PI3K-AKT pathway in temporomandibular joint osteoarthritis: an in vivo clinical trial

Abstract Background Temporomandibular joint osteoarthritis (TMJ-OA) is a subtype of temporomandibular joint disorder characterised by synovial inflammation and cartilage degradation. Endoplasmic reticulum stress (ERS) plays a critical role in osteoarthritis pathophysiology. This study aimed to inves...

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Autors principals:	Shasha Liu, Lin Sun, Jingke Fu, Bin Cai, Yongqiang Hao
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-10-01
Col·lecció:	Journal of Translational Medicine
Matèries:	Chondrocyte Phosphatidylinositol 3-Kinases Inflammation Pain Humans
Accés en línia:	https://doi.org/10.1186/s12967-025-07231-6
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