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Pharmacokinetic–pharmacodynamic analysis of cefmetazole against extended-spectrum β-lactamase-producing Enterobacteriaceae in dogs using Monte Carlo Simulation

IntroductionThe spread of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) is a serious concern in companion animal medicine owing to their ability to develop multidrug resistance. Cefmetazole (CMZ) is a candidate drug for treating ESBL-E infections; however, its regimen in dogs h...

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Principais autores: Mizuki Kusumoto, Tomoki Motegi, Haruna Uno, Mizuki Yokono, Kazuki Harada
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-09-01
Serier:Frontiers in Veterinary Science
Fag:
cefmetazole
extended-spectrum β-lactamase
Enterobacteriaceae
Monte Carlo Simulation
dog
pharmacokinetics
Online adgang:https://www.frontiersin.org/articles/10.3389/fvets.2023.1270137/full
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