Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist.

Hyperglucagonemia is implicated in the pathophysiology of hyperglycemia. Antagonism of the glucagon receptor (GCGR) thus represents a potential approach to diabetes treatment. Herein we report the characterization of GRA1, a novel small-molecule GCGR antagonist that blocks glucagon binding to the hu...

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Dettagli Bibliografici

Autori principali:	James Mu, Sajjad A Qureshi, Edward J Brady, Eric S Muise, Mari Rios Candelore, Guoqiang Jiang, Zhihua Li, Margaret S Wu, Xiaodong Yang, Qing Dallas-Yang, Corey Miller, Yusheng Xiong, Ronald B Langdon, Emma R Parmee, Bei B Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2012-01-01
Serie:	PLoS ONE
Accesso online:	http://europepmc.org/articles/PMC3501516?pdf=render
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