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Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures

ABSTRACT Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently classified according to the methionine/valine polymorphism at codon 129 of the PRNP gene and the proteinase K-digested abnormal prion protein (PrPres) isoform identified by Western blotting (type 1 or type 2). Converging evidence...

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Autori principali: Hervé Cassard, Alvina Huor, Juan-Carlos Espinosa, Jean-Yves Douet, Severine Lugan, Naima Aron, Didier Vilette, Marie-Bernadette Delisle, Alba Marín-Moreno, Patrice Peran, Vincent Beringue, Juan Maria Torres, James W. Ironside, Olivier Andreoletti
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020-06-01
Serie:mBio
Soggetti:
prion
sporadic Creutzfeldt-Jakob disease
strain diversity
evolution
diversity
prions
Accesso online:https://journals.asm.org/doi/10.1128/mBio.00393-20
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