Hypoxia-induced GRP78 activation disrupts the Fndc5/Irisin axis to accelerate skeletal muscle atrophyGene Expression Omnibus

Hypoxia is a potent inducer of skeletal muscle atrophy; however, the underlying molecular mechanisms remain incompletely defined. Irisin, a myokine derived from Fndc5, plays a critical role in maintaining muscle mass and function, while endoplasmic reticulum (ER) stress has been implicated in muscle...

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Bibliografische Detailangaben

Hauptverfasser:	Shiqiang Liu, Linyao Xu, Xinru Song, Zhenhao Zhu, Yuxin Zhang, Yumeng Sun, Sharon Nyoja, Qin Wang, Jialin Gao, Lizhuo Wang, Huiyun Xu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-05-01
Schriftenreihe:	Cell Stress & Chaperones
Schlagworte:	GRP78 Irisin Fndc5 Hypoxia Muscle atrophy
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S1355814526000325
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