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EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC

Hypoxia occurs frequently in human cancers and promotes stabilization and activation of hypoxia inducible factor (HIF). HIF-1α is specific for the hypoxia response, and its degradation mediated by three enzymes EGLN1, EGLN2 and EGLN3. Although EGLNs expression has been found to be related to prognos...

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Автори: Ruyang Zhang, Linjing Lai, Jieyu He, Chao Chen, Dongfang You, Weiwei Duan, Xuesi Dong, Ying Zhu, Lijuan Lin, Sipeng Shen, Yichen Guo, Li Su, Andrea Shafer, Sebastian Moran, Thomas Fleischer, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, Yongyue Wei, Feng Chen, David C. Christiani
Формат: Artigo
Мова:Inglês
Опубліковано: Taylor & Francis Group 2019-02-01
Серія:Epigenetics
Предмети:
egln2
hif1a
dna methylation
lung cancer
prognosis
Онлайн доступ:http://dx.doi.org/10.1080/15592294.2019.1573066
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