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Sphingomyelin synthase inhibitors from edible mushrooms prevent overweight and improve vitamin D homeostasis in a mouse model of diet-induced obesity

IntroductionSphingomyelin synthase (SMS) is a key enzyme in sphingolipid metabolism that converts phosphatidylcholine and ceramide into sphingomyelin and diacylglycerol, thereby influencing lipid signaling and metabolic regulation. Identifying natural SMS inhibitors is of interest for the prevention...

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Hauptverfasser: Enkhmaa Enkhbat, Yuta Murai, Kohei Yuyama, Hui Sun, Mahadeva M. M. Swamy, Yoshiko Suga, Masaki Anetai, Kenji Monde
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2025-12-01
Schriftenreihe:Frontiers in Nutrition
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fnut.2025.1658130/full
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