Securin overexpression correlates with the activated Rb/E2F1 pathway and histone H3 epigenetic modifications in raw areca nut-induced carcinogenesis in mice

Abstract Background Raw areca nut (RAN) consumption induces oral, esophageal and gastric cancers, which are significantly associated with the overexpression of pituitary tumor transforming gene 1/securin and chromosomal instability (CIN). An association of Securin/PTTG1 upregulation and gastric canc...

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Autores principales:	Nabamita Boruah, Chongtham Sovachandra Singh, Pooja Swargiary, Hughbert Dkhar, Anupam Chatterjee
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2022-01-01
Colección:	Cancer Cell International
Materias:	PTTG1/Securin gene Histone methylation Histone acetylation Rb phosphorylation
Acceso en línea:	https://doi.org/10.1186/s12935-022-02442-z
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