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Peri-transplant use of immune checkpoint inhibitors in hepatocellular carcinoma: a transplant oncology perspective on safety, timing, post-transplant management, and future directions

Immune checkpoint inhibitors (ICPIs) targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) pathways have transformed systemic therapy for advanced hepatocellular carcinoma (HCC), prompting exploration of their...

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Principais autores: Maen Abdelrahim, Abdullah Esmail, Bandar Al-Judaibi, Ola Khorshid, Bhoori Sherrie, Vincenzo Mazzaferro
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Oncology
Assuntos:
Hepatocellular carcinoma
immune checkpoint inhibitors
liver transplantation
Milan criteria
transplant oncology
UCSF criteria
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2026.1826765/full
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