Acute Low Dose of Trazodone Recovers Glutamate Release Efficiency and mGlu2/3 Autoreceptor Impairments in the Spinal Cord of Rats Suffering From Chronic Sciatic Ligation

We investigated whether chronic sciatic ligation modifies the glutamate release in spinal cord nerve endings (synaptosomes) as well as the expression and the function of presynaptic release-regulating mGlu2/3 autoreceptors and 5-HT2A heteroreceptors in these particles. Synaptosomes were from the spi...

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Principais autores:	Francesca Cisani, Alessandra Roggeri, Guendalina Olivero, Beatrice Garrone, Serena Tongiani, Francesco Paolo Di Giorgio, Anna Pittaluga
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2020-07-01
Serija:	Frontiers in Pharmacology
Teme:	synaptosomes mGlu2/3 receptor 5-HT2A receptor glutamate exocytosis trazodone spinal cord
Online dostop:	https://www.frontiersin.org/article/10.3389/fphar.2020.01108/full
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