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PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice

Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by the excessive accumulation of activated myofibroblasts that deposit extracellular matrix (ECM) protein, leading to progressive scar formation and mechanical stress. However, the cellular origin and fate o...

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Principais autores: Liran Xu, Ting Li, Yapeng Cao, Yu He, Zehua Shao, Siyu Liu, Bianbian Wang, Ailing Su, Huijing Tian, Yongxin Li, Guozheng Liang, Changhe Wang, John Shyy, Ying Xiong, Fangyuan Chen, Jason X.J. Yuan, Junjun Liu, Bin Zhou, Nina Wettschureck, Stefan Offermanns, Yang Yan, Zuyi Yuan, Shengpeng Wang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2025-06-01
coleção:The Journal of Clinical Investigation
Assuntos:
Cell biology
Pulmonology
Acesso em linha:https://doi.org/10.1172/JCI184158
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