The route of HIV escape from immune response targeting multiple sites is determined by the cost-benefit tradeoff of escape mutations.
Cytotoxic T lymphocytes (CTL) are a major factor in the control of HIV replication. CTL arise in acute infection, causing escape mutations to spread rapidly through the population of infected cells. As a result, the virus develops partial resistance to the immune response. The factors controlling th...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2014-10-01
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| coleção: | PLoS Computational Biology |
| Acesso em linha: | http://europepmc.org/articles/PMC4214571?pdf=render |
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