The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis

Epigenetic regulation disorder is important in the onset and pathogenesis of inflammatory bowel disease (IBD). SETD2, a trimethyltransferase of histone H3K36, is frequently mutated in IBD samples with a high risk of developing colorectal cancer (CRC). However, functions of SETD2 in IBD and colitis-a...

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Bibliografische Detailangaben

Hauptverfasser:	Min Liu, Hanyu Rao, Jing Liu, Xiaoxue Li, Wenxin Feng, Liming Gui, Huayuan Tang, Jin Xu, Wei-Qiang Gao, Li Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2021-07-01
Schriftenreihe:	Redox Biology
Schlagworte:	IBD SETD2 Oxidative stress ROS Epithelial barrier
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2213231721001622
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