The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration
The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with mitochondria at the mitochondria-associated ER membrane domain (MAM). Upon activation, the Sig-1R binds to the inositol trisphosphate...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2015-01-01
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| Serie: | Journal of Pharmacological Sciences |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S134786131400019X |
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