Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach

Introduction: Hydrocortisone is the standard of care in cortisol replacement therapy for congenital adrenal hyperplasia patients. Challenges in mimicking cortisol circadian rhythm and dosing individualization can be overcome by the support of mathematical modelling. Previously, a non-linear mixed-ef...

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Principais autores:	Robin Michelet, Davide Bindellini, Johanna Melin, Uta Neumann, Oliver Blankenstein, Wilhelm Huisinga, Trevor N. Johnson, Martin J. Whitaker, Richard Ross, Charlotte Kloft
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-01-01
coleção:	Frontiers in Pharmacology
Assuntos:	hydrocortisone congenital adrenal hyperplasia population pharmacokinetics middle-out approach pediatrics physiologically-based pharmacokinetics (PBPK)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1090554/full
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